Famous Chi Os
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| Sylvia Hitchcock Former "Miss Universe" |
Angela Kinsey Actress, The Office |
Lucy Liu Actress |
Entertainment
- Tamira A. Cole (Sigma Kappa) - Miss Black Kentucky USA, author, USA Today All-USA Academic All American and one of Glamour Magazine's Top 22 College Women
- Kathryn Crosby (Iota) - Actress
- Joyce DeWitt (Phi Epsilon) - Actress; Three's Company
- Melissa Claire Egan (Epsilon Beta) - Actress; All My Children
- Ruth Ford (Tau) - Actress
- Taryn Foshee (Phi Delta) - Miss Mississippi, 3rd runner up to Miss America
- Sylvia Hitchcock (Nu Beta) - Former "Miss Universe"
- Angela Kinsey (Theta Kappa) - Actress; The Office
- Lynne Koplitz (Iota Kappa) - Stand-up comedian
- Toby Lightman (Nu) - Singer/Songwriter
- Lucy Liu (Eta) - Actress
- Taylor Miller (Rho) - Actress; All My Children
- Mary Ann Mobley (Tau) - Former "Miss America" (1959) and Television Actress
- Lynda Mead Shea (Tau) - Former "Miss America" (1960) and owner and president of Shea-Moore Design
- Heather Thomas (Gamma Beta) - Actress
- Sela Ward (Nu Beta) - Actress; The Fugitive, Dirty Dancing Havana Nights, House
- Joanne Woodward (Phi Gamma) - Academy Award winning actress; awarded the very first star on the Hollywood Walk of Fame
Government
- Marsha Blackburn (Phi Delta) - U.S. House of Representatives
- Martha Layne Collins (Lambda Alpha) - Former Governor of Kentucky
- Shirley M. Hufstedler (Pi Gamma) - Former Secretary of the U.S. Department of Education
- Blanche Lambert Lincoln (Psi) - United States Senator from Arkansas
- Patricia Schroeder (Pi Beta) - Former Congresswoman from Colorado
- Virginia Smith (Kappa) - Former member of the U.S. House of Representatives
- Carole Keeton Strayhorn (Iota) - Texas Comptroller, ran for TX Gov (2006) as an independent
- Mabel Walker Willebrandt (Phi Alpha) - Former assistant U.S. Attorney General
Business
- Susan Athey (Mu Kappa) - Professor of Economics at Harvard University
- Alice Sheets Marriott (Xi Alpha) - Entrepreneur and philanthropist
- Nancy Walton Laurie (Psi) - Niece of Sam Walton (founder of Wal-Mart), namesake of the Leadership Institute of Chi Omega
Literature
- Ellen Gilchrist (Sigma Epsilon) - Author
- Harper Lee (Lambda Kappa) - Author, "To Kill a Mockingbird"
- Genevieve Taggard (Mu) - Author, poet
- Karen White (Rho) - Author
Sports
- Christine Brennan (Xi) - Sports Columnist and Author
- Lin Dunn (Xi Zeta) - Women's basketball coach
- Pat Summit (Xi Zeta) - Coach, University of Tennessee Lady Vols
Space Travel
- Susan Helms (Pi Gamma) - NASA Astronaut; first woman to live on the International Space Station
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| Joanne Woodward Academy Award Winning Actress |
Sela Ward Actress, The Fugitive |
Susan Helms NASA Astronaut |